Existing Data Sources in Clinical Epidemiology: The Danish COVID-19 Cohort.
Identifieur interne : 000575 ( Main/Exploration ); précédent : 000574; suivant : 000576Existing Data Sources in Clinical Epidemiology: The Danish COVID-19 Cohort.
Auteurs : Anton Potteg Rd [Danemark] ; Kasper Bruun Kristensen [Danemark] ; Mette Reilev [Danemark] ; Lars Christian Lund [Danemark] ; Martin Thomsen Ernst [Danemark] ; Jesper Hallas [Danemark] ; Reimar Wernich Thomsen [Danemark] ; Christian Fynbo Christiansen [Danemark] ; Henrik Toft S Rensen [Danemark, États-Unis] ; Nanna Borup Johansen [Danemark] ; Henrik St Vring [Danemark] ; Steffen Christensen [Danemark] ; Marianne Kragh Thomsen [Danemark] ; Anders Husby [Danemark] ; Marianne Voldstedlund [Danemark] ; Jesper Kj R [Danemark] ; Nikolai C. Brun [Danemark]Source :
- Clinical epidemiology [ 1179-1349 ] ; 2020.
Abstract
Background
To facilitate research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a prospective cohort of all Danish residents tested for SARS-CoV-2 in Denmark is established.
Data Structure
All Danish residents tested by reverse transcriptase polymerase chain reactions (RT-PCR) for SARS-CoV-2 in Denmark are included. The cohort is identified using the Danish Microbiology Database. Individual-level record linkage between administrative and health-care registries is facilitated by the Danish Civil Registration System. Information on outcomes related to SARS-CoV-2 infection includes hospital admission, intensive care unit admission, mechanical ventilation, and death and is retrieved from the five administrative Danish regions, the Danish National Patient Registry, and the Danish Register of Causes of Death. The Patient Registry further provides a complete hospital contact history of somatic and psychiatric conditions and procedures. Data on all prescriptions filled at community pharmacies are available from the Danish National Prescription Registry. Health-care authorization status is obtained from the Danish Register of Healthcare Professionals. Finally, selected laboratory values are obtained from the Register of Laboratory Results for Research. The cohort is governed by a steering committee with representatives from the Danish Medicines Agency, Statens Serum Institut, the Danish Health Authority, the Danish Health Data Authority, Danish Patients, the Faculties of Health Sciences at the Danish universities, and Danish regions. The steering committee welcomes suggestions for research studies and collaborations. Research proposals will be prioritized based on timeliness and potential clinical and public health implications. All research protocols assessing specific hypotheses for medicines will be made publicly available using the European Union electronic Register of Post-Authorisation Studies.
Conclusion
The Danish COVID-19 cohort includes all Danish residents with an RT-PCR test for SARS-CoV-2. Through individual-level linkage with existing Danish health and administrative registries, this is a valuable data source for epidemiological research on SARS-CoV-2.
DOI: 10.2147/CLEP.S257519
PubMed: 32848476
PubMed Central: PMC7429185
Affiliations:
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Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Thomsen, Reimar Wernich" sort="Thomsen, Reimar Wernich" uniqKey="Thomsen R" first="Reimar Wernich" last="Thomsen">Reimar Wernich Thomsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Christiansen, Christian Fynbo" sort="Christiansen, Christian Fynbo" uniqKey="Christiansen C" first="Christian Fynbo" last="Christiansen">Christian Fynbo Christiansen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="S Rensen, Henrik Toft" sort="S Rensen, Henrik Toft" uniqKey="S Rensen H" first="Henrik Toft" last="S Rensen">Henrik Toft S Rensen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Population Health, Stanford University, 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Anesthesia and Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Anesthesia and Intensive Care Medicine, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Kragh Thomsen, Marianne" sort="Kragh Thomsen, Marianne" uniqKey="Kragh Thomsen M" first="Marianne" last="Kragh Thomsen">Marianne Kragh Thomsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Microbiology, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Husby, Anders" sort="Husby, Anders" uniqKey="Husby A" first="Anders" last="Husby">Anders Husby</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Voldstedlund, Marianne" sort="Voldstedlund, Marianne" uniqKey="Voldstedlund M" first="Marianne" last="Voldstedlund">Marianne Voldstedlund</name><affiliation wicri:level="3"><nlm:affiliation>Infection Preparedness, Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Infection Preparedness, Statens Serum Institut, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Kj R, Jesper" sort="Kj R, Jesper" uniqKey="Kj R J" first="Jesper" last="Kj R">Jesper Kj R</name><affiliation wicri:level="3"><nlm:affiliation>Data Analytics Center, Danish Medicines Agency, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Data Analytics Center, Danish Medicines Agency, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Brun, Nikolai C" sort="Brun, Nikolai C" uniqKey="Brun N" first="Nikolai C" last="Brun">Nikolai C. Brun</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32848476</idno><idno type="pmid">32848476</idno><idno type="doi">10.2147/CLEP.S257519</idno><idno type="pmc">PMC7429185</idno><idno type="wicri:Area/Main/Corpus">000381</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000381</idno><idno type="wicri:Area/Main/Curation">000381</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000381</idno><idno type="wicri:Area/Main/Exploration">000381</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Existing Data Sources in Clinical Epidemiology: The Danish COVID-19 Cohort.</title><author><name sortKey="Potteg Rd, Anton" sort="Potteg Rd, Anton" uniqKey="Potteg Rd A" first="Anton" last="Potteg Rd">Anton Potteg Rd</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Kristensen, Kasper Bruun" sort="Kristensen, Kasper Bruun" uniqKey="Kristensen K" first="Kasper Bruun" last="Kristensen">Kasper Bruun Kristensen</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Reilev, Mette" sort="Reilev, Mette" uniqKey="Reilev M" first="Mette" last="Reilev">Mette Reilev</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Lund, Lars Christian" sort="Lund, Lars Christian" uniqKey="Lund L" first="Lars Christian" last="Lund">Lars Christian Lund</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Ernst, Martin Thomsen" sort="Ernst, Martin Thomsen" uniqKey="Ernst M" first="Martin Thomsen" last="Ernst">Martin Thomsen Ernst</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Hallas, Jesper" sort="Hallas, Jesper" uniqKey="Hallas J" first="Jesper" last="Hallas">Jesper Hallas</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Biochemistry and Clinical Pharmacology, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry and Clinical Pharmacology, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Thomsen, Reimar Wernich" sort="Thomsen, Reimar Wernich" uniqKey="Thomsen R" first="Reimar Wernich" last="Thomsen">Reimar Wernich Thomsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Christiansen, Christian Fynbo" sort="Christiansen, Christian Fynbo" uniqKey="Christiansen C" first="Christian Fynbo" last="Christiansen">Christian Fynbo Christiansen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="S Rensen, Henrik Toft" sort="S Rensen, Henrik Toft" uniqKey="S Rensen H" first="Henrik Toft" last="S Rensen">Henrik Toft S Rensen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Population Health, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Johansen, Nanna Borup" sort="Johansen, Nanna Borup" uniqKey="Johansen N" first="Nanna Borup" last="Johansen">Nanna Borup Johansen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="St Vring, Henrik" sort="St Vring, Henrik" uniqKey="St Vring H" first="Henrik" last="St Vring">Henrik St Vring</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health - Biostatistics, Aarhus University, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Public Health - Biostatistics, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Christensen, Steffen" sort="Christensen, Steffen" uniqKey="Christensen S" first="Steffen" last="Christensen">Steffen Christensen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesia and Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Anesthesia and Intensive Care Medicine, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Kragh Thomsen, Marianne" sort="Kragh Thomsen, Marianne" uniqKey="Kragh Thomsen M" first="Marianne" last="Kragh Thomsen">Marianne Kragh Thomsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Microbiology, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Husby, Anders" sort="Husby, Anders" uniqKey="Husby A" first="Anders" last="Husby">Anders Husby</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Voldstedlund, Marianne" sort="Voldstedlund, Marianne" uniqKey="Voldstedlund M" first="Marianne" last="Voldstedlund">Marianne Voldstedlund</name><affiliation wicri:level="3"><nlm:affiliation>Infection Preparedness, Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Infection Preparedness, Statens Serum Institut, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Kj R, Jesper" sort="Kj R, Jesper" uniqKey="Kj R J" first="Jesper" last="Kj R">Jesper Kj R</name><affiliation wicri:level="3"><nlm:affiliation>Data Analytics Center, Danish Medicines Agency, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Data Analytics Center, Danish Medicines Agency, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Brun, Nikolai C" sort="Brun, Nikolai C" uniqKey="Brun N" first="Nikolai C" last="Brun">Nikolai C. Brun</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></analytic><series><title level="j">Clinical epidemiology</title><idno type="ISSN">1179-1349</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background</b></p><p>To facilitate research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a prospective cohort of all Danish residents tested for SARS-CoV-2 in Denmark is established.</p></div><div type="abstract" xml:lang="en"><p><b>Data Structure</b></p><p>All Danish residents tested by reverse transcriptase polymerase chain reactions (RT-PCR) for SARS-CoV-2 in Denmark are included. The cohort is identified using the Danish Microbiology Database. Individual-level record linkage between administrative and health-care registries is facilitated by the Danish Civil Registration System. Information on outcomes related to SARS-CoV-2 infection includes hospital admission, intensive care unit admission, mechanical ventilation, and death and is retrieved from the five administrative Danish regions, the Danish National Patient Registry, and the Danish Register of Causes of Death. The Patient Registry further provides a complete hospital contact history of somatic and psychiatric conditions and procedures. Data on all prescriptions filled at community pharmacies are available from the Danish National Prescription Registry. Health-care authorization status is obtained from the Danish Register of Healthcare Professionals. Finally, selected laboratory values are obtained from the Register of Laboratory Results for Research. The cohort is governed by a steering committee with representatives from the Danish Medicines Agency, Statens Serum Institut, the Danish Health Authority, the Danish Health Data Authority, Danish Patients, the Faculties of Health Sciences at the Danish universities, and Danish regions. The steering committee welcomes suggestions for research studies and collaborations. Research proposals will be prioritized based on timeliness and potential clinical and public health implications. All research protocols assessing specific hypotheses for medicines will be made publicly available using the European Union electronic Register of Post-Authorisation Studies.</p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>The Danish COVID-19 cohort includes all Danish residents with an RT-PCR test for SARS-CoV-2. Through individual-level linkage with existing Danish health and administrative registries, this is a valuable data source for epidemiological research on SARS-CoV-2.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32848476</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1179-1349</ISSN><JournalIssue CitedMedium="Print"><Volume>12</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Clinical epidemiology</Title><ISOAbbreviation>Clin Epidemiol</ISOAbbreviation></Journal><ArticleTitle>Existing Data Sources in Clinical Epidemiology: The Danish COVID-19 Cohort.</ArticleTitle><Pagination><MedlinePgn>875-881</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2147/CLEP.S257519</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">To facilitate research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a prospective cohort of all Danish residents tested for SARS-CoV-2 in Denmark is established.</AbstractText><AbstractText Label="Data Structure" NlmCategory="UNASSIGNED">All Danish residents tested by reverse transcriptase polymerase chain reactions (RT-PCR) for SARS-CoV-2 in Denmark are included. The cohort is identified using the Danish Microbiology Database. Individual-level record linkage between administrative and health-care registries is facilitated by the Danish Civil Registration System. Information on outcomes related to SARS-CoV-2 infection includes hospital admission, intensive care unit admission, mechanical ventilation, and death and is retrieved from the five administrative Danish regions, the Danish National Patient Registry, and the Danish Register of Causes of Death. The Patient Registry further provides a complete hospital contact history of somatic and psychiatric conditions and procedures. Data on all prescriptions filled at community pharmacies are available from the Danish National Prescription Registry. Health-care authorization status is obtained from the Danish Register of Healthcare Professionals. Finally, selected laboratory values are obtained from the Register of Laboratory Results for Research. The cohort is governed by a steering committee with representatives from the Danish Medicines Agency, Statens Serum Institut, the Danish Health Authority, the Danish Health Data Authority, Danish Patients, the Faculties of Health Sciences at the Danish universities, and Danish regions. The steering committee welcomes suggestions for research studies and collaborations. Research proposals will be prioritized based on timeliness and potential clinical and public health implications. All research protocols assessing specific hypotheses for medicines will be made publicly available using the European Union electronic Register of Post-Authorisation Studies.</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">The Danish COVID-19 cohort includes all Danish residents with an RT-PCR test for SARS-CoV-2. Through individual-level linkage with existing Danish health and administrative registries, this is a valuable data source for epidemiological research on SARS-CoV-2.</AbstractText><CopyrightInformation>© 2020 Pottegård et al.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pottegård</LastName><ForeName>Anton</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0001-9314-5679</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kristensen</LastName><ForeName>Kasper Bruun</ForeName><Initials>KB</Initials><AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reilev</LastName><ForeName>Mette</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lund</LastName><ForeName>Lars Christian</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ernst</LastName><ForeName>Martin Thomsen</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hallas</LastName><ForeName>Jesper</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-8097-8708</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Biochemistry and Clinical Pharmacology, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomsen</LastName><ForeName>Reimar Wernich</ForeName><Initials>RW</Initials><Identifier Source="ORCID">0000-0001-9135-3474</Identifier><AffiliationInfo><Affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Christiansen</LastName><ForeName>Christian Fynbo</ForeName><Initials>CF</Initials><Identifier Source="ORCID">0000-0002-0727-953X</Identifier><AffiliationInfo><Affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sørensen</LastName><ForeName>Henrik Toft</ForeName><Initials>HT</Initials><Identifier Source="ORCID">0000-0003-4299-7040</Identifier><AffiliationInfo><Affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johansen</LastName><ForeName>Nanna Borup</ForeName><Initials>NB</Initials><AffiliationInfo><Affiliation>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Støvring</LastName><ForeName>Henrik</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0002-5821-2351</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Public Health - Biostatistics, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Christensen</LastName><ForeName>Steffen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kragh Thomsen</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-3645-6689</Identifier><AffiliationInfo><Affiliation>Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Husby</LastName><ForeName>Anders</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Voldstedlund</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Infection Preparedness, Statens Serum Institut, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kjær</LastName><ForeName>Jesper</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Data Analytics Center, Danish Medicines Agency, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brun</LastName><ForeName>Nikolai C</ForeName><Initials>NC</Initials><AffiliationInfo><Affiliation>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>New Zealand</Country><MedlineTA>Clin Epidemiol</MedlineTA><NlmUniqueID>101531700</NlmUniqueID><ISSNLinking>1179-1349</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Covid-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">database</Keyword><Keyword MajorTopicYN="N">epidemiology</Keyword><Keyword MajorTopicYN="N">follow-up</Keyword><Keyword MajorTopicYN="N">prognosis</Keyword><Keyword MajorTopicYN="N">prospective cohort</Keyword></KeywordList><CoiStatement>KBK, NBJ, MAV, SC, NB, AH, JK, MTE, and MKT declare no conflicts of interest. RWT, CFC, and HTS declare no personal conflicts of interest. The Department of Clinical Epidemiology is involved in studies with funding from various companies as research grants to and administered by Aarhus University. None of these studies are related to the current study. HS reports personal fees from Bristol-Myers Squibb, Novartis, and Roche, outside the submitted work. AP and JH report participation in research funded by Alcon, Almirall, Astellas, AstraZeneca, Boehringer-Ingelheim, Novo Nordisk, Servier, and LEO Pharma, all with funds paid to the institution where they were employed (no personal fees) and with no relation to the work reported in this paper. LCL reports participation in research projects funded by Menarini Pharmaceutical and LEO Pharma, with funds paid to the institution where he was employed (no personal fees) and with no relation to the work reported in this paper. MR reports participation in research projects funded by LEO Pharma, with funds paid to the institution where she was employed (no personal fees) and with no relation to the work reported in this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32848476</ArticleId><ArticleId IdType="doi">10.2147/CLEP.S257519</ArticleId><ArticleId IdType="pii">257519</ArticleId><ArticleId IdType="pmc">PMC7429185</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>N Engl J Med. 2020 May 21;382(21):1969-1973</Citation><ArticleIdList><ArticleId IdType="pubmed">32227757</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacoepidemiol Drug Saf. 2018 Mar;27(3):245-252</Citation><ArticleIdList><ArticleId IdType="pubmed">29327451</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Epidemiol. 2017 Jun 1;46(3):798-798f</Citation><ArticleIdList><ArticleId IdType="pubmed">27789670</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Heart J. 2020 May 14;41(19):1801-1803</Citation><ArticleIdList><ArticleId IdType="pubmed">32196087</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Epidemiol. 2019 Jul 12;11:563-591</Citation><ArticleIdList><ArticleId IdType="pubmed">31372058</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2018 Nov 14;363:k3532</Citation><ArticleIdList><ArticleId IdType="pubmed">30429167</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Epidemiol. 2016 Oct 25;8:525-530</Citation><ArticleIdList><ArticleId IdType="pubmed">27822095</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2020 Mar 17;368:m1086</Citation><ArticleIdList><ArticleId IdType="pubmed">32184201</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2020 Apr;8(4):e21</Citation><ArticleIdList><ArticleId IdType="pubmed">32171062</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacoepidemiol Drug Saf. 2020 Aug;29(8):825-831</Citation><ArticleIdList><ArticleId IdType="pubmed">32369865</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2020 Aug;584(7820):257-261</Citation><ArticleIdList><ArticleId IdType="pubmed">32512579</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2007 Oct 16;147(8):W163-94</Citation><ArticleIdList><ArticleId IdType="pubmed">17938389</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Med. 2015 Oct 06;12(10):e1001885</Citation><ArticleIdList><ArticleId IdType="pubmed">26440803</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Epidemiol. 2015 Nov 17;7:449-90</Citation><ArticleIdList><ArticleId IdType="pubmed">26604824</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Epidemiol. 2014 Aug;29(8):541-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24965263</ArticleId></ArticleIdList></Reference><Reference><Citation>Scand J Public Health. 2011 Jul;39(7 Suppl):54-7</Citation><ArticleIdList><ArticleId IdType="pubmed">21775352</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation><ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId></ArticleIdList></Reference><Reference><Citation>Epidemiology. 2019 Nov;30(6):838-844</Citation><ArticleIdList><ArticleId IdType="pubmed">31430265</ArticleId></ArticleIdList></Reference><Reference><Citation>Scand J Public Health. 2011 Jul;39(7 Suppl):26-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21775346</ArticleId></ArticleIdList></Reference><Reference><Citation>Euro Surveill. 2014 Jan 09;19(1):</Citation><ArticleIdList><ArticleId IdType="pubmed">24434175</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Danemark</li><li>États-Unis</li></country><region><li>Californie</li><li>Hovedstaden</li></region><settlement><li>Copenhague</li><li>Stanford (Californie)</li></settlement><orgName><li>Université Stanford</li></orgName></list><tree><country name="Danemark"><noRegion><name sortKey="Potteg Rd, Anton" sort="Potteg Rd, Anton" uniqKey="Potteg Rd A" first="Anton" last="Potteg Rd">Anton Potteg Rd</name></noRegion><name sortKey="Brun, Nikolai C" sort="Brun, Nikolai C" uniqKey="Brun N" first="Nikolai C" last="Brun">Nikolai C. 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